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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1243d4453c728146fab467e34f9d3d4ba8aa440078d3b5f8ff8d48faf49fe2b6' 
  AND token = 'AOiGF4IUxh5eer+erKtOLuvf+NpkdpU4vXHKoU79Mm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}