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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d5594201c07a8464f8996fa87803df2a06528486643a661017250bf65456f67' 
  AND token = '0J+KxlW8Bm7Inp5WX3spT2BHGcLFYWhL6TTHgTui3vQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}