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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '165ef194f2abf8f0547c06bf0802d7868a1d245135d59c5478d924379d85b47d' 
  AND token = 'Z5s/MenIPeLxh/Juomu9FH7Zf6PnG4cFb89Ieuzx8LI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}