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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1224a5795a1dc99a8ae8ad51182dfb7a279b81999e6e6a43e56d6f6036c706c4' 
  AND token = 'm6lCbE4fPcq+iRkj2qGvHEtC5C7yTcke3QPCaY2KZJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}