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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b41c5f8a23d45cdf9321f659adf1b3b1014e3a3832e157dd3a3e198be025315' 
  AND token = 'x7IdVVsZj2LEwHoa09D+anb9JF1XO2T9ywlAb65YTnE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}