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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '722978a4fbf25039e0b74b5a2c8820ad83e16f835a1e463972a3e4f0df69ff5f' 
  AND token = '2wf1MM8jpkQImuTcnTzHj5KCXsJO9uA8st1+NcgXJwg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}