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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8336a894050ebfc4ad38d2c1177e002c8dbba37bbd4df33239428753dd0cb1f1' 
  AND token = 'gH4ejR8Jp8eLONi858xnJSB2uOiGXY1xTfEB1RIIFU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}