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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '481b17332f31e9d827ee8b4f1e2bfe25d3f194aecb0f6bdf5dba60f285db66d1' 
  AND token = 'C2f8fIjsANqrRoOwn5mhjT+uvErw4jR4wD0an6THjAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}