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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b3100ed8a226280ed4d7d667eaec383b9aaca68f7ba5a6cfa09c1dc52116a5a' 
  AND token = 'a2xyhz8nrwsrOPtp+mQIIA9ncmyxqhW/wDc51OaVos4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}