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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21fe1a5d19b14e69e9439ceddc84e2d20ce32139d75d856aabcb85eeacdd10f4' 
  AND token = 'JIYHeinbp0ngpZJEbTvGTaVrPpUqLcqVFdRh6jK7xj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}