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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f39d292ea26f076613790157fc62b517758f8b3a24f5450848841232ce1c503' 
  AND token = 'q7ipOHm8xqE0Uim8vNcKxTH8qmO+Y7bscaZ8yEBAaYs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}