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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e6ec80b578343e416e5da184aab0f24e42a0d2295d6464a11bb42941c7432f6' 
  AND token = 'ctm2ggcckoGOURaBn0ihkxEsCuNC3f6vFsMDMVj5dLs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}