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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b12fde705656fb5f7e19319ff185a4ccdbbe8617e4d172ec0d76302395ebe799' 
  AND token = 'R8mX8qaRgWiUiqPFNOJSHwYE6UFPyUQX5Kp2YxPS+iI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}