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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ab6dc045f6cbc94d5ac3f279be5f9cfcb892cecad03a5c4198896b34426e564' 
  AND token = 'mSJeunTp8Uy64yLyhFY1pv94A6gaTp3ger21oly23UU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}