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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4314b48ec4e028594e57bbd061cc3c57418e7229f1aa7449828525303b16f465' 
  AND token = 'Ulmp+IafpRiKfs/c3iJbQ8pIuEdE44m/eAwDYFYs4UE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}