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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9d9256764943a958633e2e3783985d75206281212dd6327c0f342ce912c00efe' 
  AND token = 'y4bD1EG6ETY+Icw+3mWtXlQaEhMfKht0xaTGl/G5qMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}