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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44425fcde44fb2018fbdc4b4ee9edb0f4197be183d22933d845d97c540b4540c' 
  AND token = '6a2mTXkDZ7D/XhUKPenjsxDereGOmvVsw1ZNDAgm49w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}