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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5bc88fc0d07cfbce8e681e29dfdc3a820d0e38774219f640ffb51980da2cd78' 
  AND token = 'rS00T5qlxqpWFkdDFX5nup9GwhUUNTvEsm+Z/3PNOeo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}