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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f9a729fa7a5cb1fde87688e4b5226320d06d2c738821275e23184ef7903f5677' 
  AND token = 'iEt8043x3LFL1bVCDQj9QaUnGEsaCezvkHKCLs3Dxk0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}