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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6422189e3d6d9371372dde73345bbdb2c3adb0d9a2bad20b1eae87c34195f0cb' 
  AND token = '757/IFTLiupXG2R5BWtrR12hpBRxgwYG0y0O0cXZVH8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}