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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '049f59a193e7b9d696b057af53a0a629bec17383512bf3a4e1c3a9609d1815aa' 
  AND token = 'sJ500xHo7w9fuhuVNg4LqBZkMwpB7IS0RQy+zCCncaA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}