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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '546366c3b6b2e7f9255f58656bd889811efa9fb75dc3aaa1ca2cb594baadb10e' 
  AND token = 'CKkFCd9W7poCyrLBDeLquQDaOWiGIy1352LkdINbLUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}