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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b22220cc43dab2fe5af7a6935861361d35b9aa0f51a6d55a9e018ac9ee35721d' 
  AND token = 'eYlOOR4zFymjshvHiYLe8ZfCDit5P1mEpD3PwH4MKBw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}