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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4465eef612886dac99374548387a327e974a24ef18bc16206cbf2342f1be1646' 
  AND token = 'Cjj5lhFRU4Zh/VhD0a8QGXCD4QQqm3RC9poLFNQN29s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}