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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '621c9a21e5ec44d7e7f6bba9a324d05102f86b100b6a0743e9763f48ff1f60df' 
  AND token = '4Ud4zYWxsAR+isGtaQRb/DzKryFuN/+00Qf2bLMCygg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}