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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ad59003a2184249ecba7353c425c94303d195373b8de1e3b07f4a777c40b2d1' 
  AND token = 'cEk8rhDsQaeDW+X8K4sJwMtEB/UJ3wCVbACjMw9v0SI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}