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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c86def5ed8c32d6c68ff24415a97ec3d6b508bbc32e1018ab33aa3c54351cc06' 
  AND token = '4iiBfiC7VdEl/Cf3zoB+XjxBR8xwFTpmU4gJdwwS6Ko=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}