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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2886e47e1acd3081b2c6e1d70fdde02c48e30e0497f34ce515d841b3bd2e8b2d' 
  AND token = 'RSS+PzmoeHmuCMvrBC93a2/4UOjG80uDMnQSeMXgjq4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}