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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d4bb38201035a939b51a003c0af300693c4784ac2fdd1f0584acb65fe3a49f6' 
  AND token = 'PryxpuXe+RTe3pNN6As1+8WCXspP4Tx/qs0dJOY8q70=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}