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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a453f74b5ea589a00d38a3d778dc81630b8da24ea31904c9caa2e6e9896984' 
  AND token = 'peK+GGAxHXYPP0E8P7I0g3NfzRZKuKX32dEZxAiM4ns=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}