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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6b72f58f88a7482a7daa6f67012c0ab15ee3363ae68f6bd72c22349968015b1' 
  AND token = 'YVyLoCbVqDUT+fVYgHqSuT0yLXT5dOyOqS8OFT3kCi4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}