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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e047fde55c3f38ec3238f2a107c7c6c4745ddfde8a57e43a5bf3349b66392da' 
  AND token = 'S1fCbaUexCsu7H0MuYGrZgNRR2NOmgqGH3a+nkGJ+c0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}