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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4049a974d7c026b2549fe681db2d1c40d1f389d09abc457d9ed863e9036de18a' 
  AND token = 'woB3qWwKQJk/w99ZugxaSXaCxV4+lQqCVeW7QcdRAO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}