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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d46d17e12279bb5a8eb2b01e8e45dd992cb1d516565dc59fbd4b2856af4ef1c' 
  AND token = '1b0Jv9AhaGRnjXAoQiQRMQTDFdG5h4N5gcnPl/eAIV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}