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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ab439d659ee80bdd61db1e365167061115c1648f834c1f03257e09b16c54fe90' 
  AND token = 'ML2f4W6bFW3GBJtluc3w+amhK619YzUP5uk243TH7Sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}