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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0142dd04106e97b7bb964f9aea0cfe5c2e489a1325a2c30348b1fef3e29962f8' 
  AND token = 'z7dWkGRb4hNN3ihsLnFkazMyvP0m/GkUBXyzG6sG7Ok=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}