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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b3f48513eb50e0e33144766e0fb0141238e4e968a628ebc6e2fe71c88d963a' 
  AND token = 'PvlZURZSsLj+08ZX05Aay0qxrqL9SmUgHct+wNmmR44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}