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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721ccdada3d4c7b37771560603d3160304cd49f03ffc63eacb35c0aeab675dea' 
  AND token = 'cy4iTPUJS2vdKwRHfo+eVGtxma7/GtzAq5E2X7UV9Fc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}