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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b545a8b21269a6ca2a141931054a4f1d4002d590be5ed19854cdad4b76e604' 
  AND token = 'OkjuRs0zfUY2xB+HXNEAnQMvUMLUT7CMfoKvvTbVGEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}