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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a80eee9013443fb86c722dc72b2b7aa400d3ed7d3863e6195a8d0f4c9f042366' 
  AND token = 'VMARca9+igggbF0vgMyp/EHWloby8I+6r4O2zSZWwFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}