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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d7624a97d3e8fc664cbc5a80dc6140179f433af9c0d704d4243afac9fc0462c' 
  AND token = 'VxYeqT5/8t6i4YqHyExdMwRSFPIJ55jBBvScdGtUjy8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}