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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27da01cdde1d7342c5432823c567441a7a97cd53789c9bd09e4c4e6700d43a81' 
  AND token = 'nz1k8ZU7vxEuOcCkgcVXmGX+zxnO0ClrEyT6PLogguk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}