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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849aad5018df027bc07d2db75016f83d7f74c0be5121f86cd9a3546b29dd15cb' 
  AND token = '6yd6/iSgxNxjTpCH2bZrL5KZDooO2j4xm8HCBWKObMI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}