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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78370d39f0a4378e8bb251e512047587bb6ad79d70231bf1dadac180e8d4df5f' 
  AND token = 'lgkZ8ZFrg098AsYMoE6XwzOtR+2XzSJAPJx52uojMAY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}