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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '345ac6077e7501c4aefe66d249ba0e2fefd837cf09a9c788554b6f20c8069de6' 
  AND token = 'TkFYJxJ4+GEf9tGCW8v4HNd4F5dNu3Z00WxsAhC7Hz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}