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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '76fce7cef90d02035046bf1841e7af4bb2e009cd66ad631e57e6a218541be642' 
  AND token = 'M01zU0+/gIMEA2H/pVUusDdyNwF6WaMouTVz2S0rpOI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}