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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21f21feefbee3d72b228a25be3cf68b6497c2117317373f6cedb709d760e39f3' 
  AND token = 'Qy5k3JiqsnhHV9l+0l8TGEsk2USWoygZ9IRLpIAoxZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}