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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12a63f280cc1c8364ef4f3c9613ca47a00bd16f1d0e39650c2229c22a6b44dbe' 
  AND token = 'x1RjlCMfknnsiYmzxUTa7tlxF+vXv36niwzxl0SDQ7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00074

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}