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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '355d2de046183f0894748a8741036c51e75dd8953ed081d2c2a61826c0e979ce' 
  AND token = '+6AC+ApPiwMDnFowYCOre7nuZG3IHTgy+/QpNr/Mn7c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}