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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da74546286d177ad1c18f416f9592b6d0e19dd3371bc14f29142bb321083e9f0' 
  AND token = 'hXTF3m+GNIa9ZbJJ3C8pWKnZoN4NLArGAwQLjDatbhw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}